Resistance to telithromycin is conferred by msr(A), msrC and msr(D) in Staphylococcus aureus

Resistance to telithromycin is conferred by msr(A), msrC and msr(D) in Staphylococcus aureus.

Sir, The antibiotic resistance determinants Msr(A), MsrC and Msr(D) are all members of a group of ‘incomplete’ or Class 2 ABC transporters, characterized by the presence of two fused nucleotidebinding domains but lacking any identifiable transmembrane domains, and are typically involved in cellular processes other than transport. The msr(A) gene is carried on large staphylococcal plasmids, and ...

Enhanced resistance to erythromycin is conferred by the enterococcal msrC determinant in Staphylococcus aureus.

OBJECTIVES The msrC gene, found on the chromosome of Enterococcus faecium, shares a high degree of similarity with the staphylococcal erythromycin resistance determinant msr(A). The enterococcal determinant was cloned into Staphylococcus aureus to determine whether msrC could confer antibiotic resistance in staphylococci. METHODS A shuttle vector comprising pBluescript and pSK265 was used to ...

Vancomycin Resistance in Staphylococcus aureus Strains

Prevalence of clindamycin-resistant Staphylococcus aureus induced by macrolide resistance

Introduction: Since the incidence of various infections caused by Staphylococcus aureus increases, the use of effective antibiotics such as clindamycin has been growing to treat the systemic and local infections caused by such organisms. Antibiotic-resistant species are emerging and spreading in today's communities due to misuse of antibiotics and incomplete treatment, turning into a serious ch...

Detection Of Methicillin Resistance In Staphylococcus Aureus By Disk Diffusion And PCR Methods

  Background and Objective: Methicillin resistance in Staphylococcus aureus is an increasingly important clinical problem. A chromosomal gene, mecA, mediates resistance to penicillinase-resistant penicillins such as methicillin and oxacillin in Staphylococcus aureus. We evaluated the validity of disk diffusion test by using oxacillin, methicillin an...